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Published on 06 March 2011

THE ANALYSIS OF TOXIC INFLUENCE OF HEAVY METALS SALTS ON THE BASIC MEDICOBIOLOGICAL PARAMETERS OF HEALTH IN EXPERIMENT AND CLINICS

Dzugkoeva F.S., Khetagurova L.G., Chopikashvili L.V., Kasokhov A.B., Dzugkoev S.G.

The salts of heavy metals induce formation of oxygen active forms initiating lipoperoxidation (LPO) in erythrocyte and renal tissues and infringement of superoxide-dismutase and catalyses activity. The secondary products of LPO cause disfunction of an endothelium and development of toxic angio- and nephropathy. The children, living in ecologically unsuccessful areas of Vladikavkaz, have oppression of immune reactance, decrease in the maintenance antiinflammatory cytokines and increase in proinflammatory concentration, it leads to an exacerbation of a bronchial asthma. Heavy metals salts of are the reason of the genovariations leading to the infringement of genital function of women of reproductive age and congenital developmental anomalies of newborns. Thus prooxidanst render cytotoxic action at a molecular-genetic level, and break neurohumoral mechanisms of regulation visceral systems, promoting formation of the special form of pathological process – vicious circle.

CityVladikavkaz
CountryRussia
UDC577.352.3
Issue2011, № 1(7)
Key words nickel, cobalt, cadmium, lipoperoxidation, kidneys, chromosomal aberrations, bronchial asthma, cytokines
Number of views (1240)

Categories: Articles, Geo-ecological,-Recreational-and-Biomedical-Issues-of-SDMT

Tags: хромосомные аберрации, никель, кобальт, кадмий, перекисное окисление липидов, почки, бронхиальная астма, цитокины.

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ISSN 1998-4502 (Print)                                                            ISSN 2499-975Х (Online)