The automatic switches (AS) are part of hardware of the system for samples delivery for analysis and designed to change the transport container movement direction. The automatic switches are adaptable in design and perform two functions: transfer of a transport container from several to one transportation tubes and transfer of a transport container from one to several transportation tubes. The most practical and common are automatic switches “From 2 to 1” and “From 4 to 4”. The paper examines in detail the functions of the automatic switches “From 2 to 1” and “From 4 to 4” and considers their design features and operating principle. It also discusses automatic operation control algorithms for automatic switches “From 2 to 1” and “From 4 to 4”.